Weak base dispiro-1,2,4-trioxolanes: potent antimalarial ozonides.
نویسندگان
چکیده
Thirty weak base 1,2,4-dispiro trioxolanes (secondary ozonides) were synthesized. Amino amide trioxolanes had the best combination of antimalarial and biopharmaceutical properties. Guanidine, aminoxy, and amino acid trioxolanes had poor antimalarial activity. Lipophilic trioxolanes were less stable metabolically than their more polar counterparts.
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 17 5 شماره
صفحات -
تاریخ انتشار 2007